|
KMID : 0370219830270020177
|
|
Yakhak Hoeji
1983 Volume.27 No. 2 p.177 ~ p.179
|
|
|
Preparation of epsilon-N-[(2-Chloroethyl) nitrosocarbamoyl]-L-lysine
|
|
김정균/Kim JC
조인섭/Cho IS
|
|
|
Abstract
|
|
|
|
A copper complex of epsilon-N-[(2-chloroethyl)carbamoyl]-L-lysine was prepared by the treatment of the L-lysine copper complex with 2-chloroethyl isocyanate in cold water. Within the L-lysine copper complex molecule, the alpha-amino and carboxyl groups are bounded to Cu2+, but the epsilon-amino group is free and can react with carbamoylating agents. A potential antitumor agent, epsilon-N-[(2-chloroethyl) nitrosocarbamoyl]-L-lysine was synthesized by nitrosation of this copper complex with Na N02 in anhydrous formic acid, followed by the passage of H2S gas.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|